GrantZIABC
Isolation and Purification of Cancer Stem Cells Based on Functional Approaches
- Activity
- ZIA
- Institute
- BC
- Fiscal years
- 2011–2012
- Amount counted
- $376,698
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Abstract public domain (NIH RePORTER)
In this project we investigate wide array of cancers: hepatocellular carcinoma, cholangiocarcinoma, pancreatic adenocarcinoma, breast cancer, melanoma, and gastric cancersThis project has two prongs:One, where we use a functional approach to identify the "best" cancer stem cell usiong all previously described methodes and markers and subjecting them to a rigorous tesing methodology. Once identified we will try to target these cells via the specific marker in attempt to generate novel cancer therapy.Two, using a novel methodology we try to isolate the self renwing cells via asymmetric division in various cancers and determine whether these are the "fitest" cancer stem cells