Journal articleCell Rep2021
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.
- Journal
- Cell Rep
- Published
- 1 June 2021
- Citations
- 39
- Type
- Article
- License
- cc by-nc-nd
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Grants 16
- Validation of WEE1 kinase as a clinical target in KRAS-mutant pancreatic cancer F30CA243253↗
- K-Ras mutant-specific vulnerabilities for novel pancreatic cancer therapies F32CA200313↗
- Targeting CDK4/6 for pancreatic cancer treatment F32CA221005↗
- Defining the contributions of WT RAS in RAS-mutant lung cancer F32CA232529↗
- Defining the roles of ERK MAPK in driving KRAS-mutant pancreatic cancer growth. F32CA239328↗
- Functional interrogation of epigenetic vulnerabilities in KRAS-mutant pancreatic cancer K08CA218420↗
- Project 3: Mechanisms and therapeutic targeting of NRAS in melanoma P01CA203657↗
- Defining the KRAS mutation specific interactions in pancreas cancer P20GM130457↗
- Project 3 - Improving Therapy for DNA-Damage Deficient Pancreatic Adenocarcinoma P50CA127003↗
- Project 1: Overcoming Tumor-Induced Immune Suppression to Improve Responses to Immunotherapy P50CA196510↗
- Biological Activity of Ras Oncogenes R01CA042978↗
- Mechanisms of PAK1 activation, signaling and tumor resistance R01CA175747↗
- ERK inhibitor resistance and ERK isoform-dependent growth in pancreatic cancer R21CA179193↗
- Targeting undruggable RAS for cancer treatment R35CA232113↗
- Identification of synthetic lethal interactors in pancreatic cancer U01CA199235↗
- Systematic interrogation of the pancreatic cancer microenvironment in patient-derived specimens U01CA224146↗