Journal articleCancer Discov2024

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer.

DOI 10.1158/2159-8290.cd-24-0177 ↗ OpenAlex, retrieved 5 November 2026

Journal: Cancer Discov
Published: 1 November 2024
Citations: 289
Type: Article
License: cc by-nc-nd

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Trials 1

BackgroundA Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid … NCT03600883 ↗

Grants 5

Regulation and targeting of tumor cell states and plasticity in pancreatic cancer K08CA260442 ↗
Project 3 - Improving Therapy for DNA-Damage Deficient Pancreatic Adenocarcinoma P50CA127003 ↗
Administrative Core P50CA221707 ↗
Mechanisms of response and resistance to KRAS inhibition in pancreatic cancer R01CA276268 ↗
Stromal modulation of pancreatic cancer malignant cell state and therapeutic sensitivity U01CA274276 ↗