Clinical trialPhase 1Withdrawn
The Role of Meat-borne Carcinogens in Pancreatic Cancer
Understanding the Role of Meat-Borne Carcinogen in Pancreatic Cancer Etiology
- Outcome
- Stopped earlyNeeded New IND per FDA (Business decision)
- Phase
- Phase 1
- Status
- Withdrawn
- Study type
- Interventional
- Start
- January 2012
- Expected end
- January 2012
- Enrollment
- 0 participants
- Sites
- 1
- Primary outcomes
- Quantify and characterize HCA-DNA adducts in resected human pancreatic tissue after a dietary relevant dose of PhIP, the most mass abundant HCA in charred meat.
- Sponsor
- Other
- Results posted
- No
- Last update
- 26 June 2020
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Brief summary public domain (ClinicalTrials.gov)
We propose to recruit subjects scheduled for pancreatectomy as a treatment for pancreatic cancer. These subjects will ingest a very low dose of radiolabeled PhIP, a meat-derived carcinogen, and a small amount of resected tissue (waste) will be analyzed with highly sensitive technology to determine if this carcinogen binds to DNA in the pancreas.
Detailed description public domain (ClinicalTrials.gov)
Pancreatic cancer is rapidly fatal in most cases and little is known about its causes. Identifying and modifying risk factors can reduce mortality through prevention. Carcinogens that form in meat cooked at high temperatures may be modifiable risk factors for pancreatic cancer, but direct evidence is needed to demonstrate involvement in pancreas tissue. We propose to recruit subjects scheduled for pancreatectomy as a treatment for pancreatic cancer. These subjects will ingest a very low dose of radiolabeled PhIP, a meat-derived carcinogen, and a small amount of resected tissue (waste) will be analyzed with highly sensitive technology to determine if this carcinogen binds to DNA in the pancreas. We hypothesize that the meat-derived carcinogen will bind to DNA in the pancreas. The amount of PhIP ingested is equivalent to the amount in two very well-done barbecued chicken breasts and the dose of radioactivity is comparable to a typical chest x-ray. This research can increase understanding of pancreatic carcinogenesis, facilitating the design of prevention strategies.