Clinical trialNARecruiting
Computed Tomography in Diagnosing Patients With Pancreatic or Hepatobiliary Cancer
Imaging Biomarkers in Pancreatic and Hepatobiliary Cancers
- Outcome
- Ongoing
- Phase
- NA
- Status
- Recruiting
- Study type
- Interventional
- Start
- 9 March 2015
- Expected end
- 27 June 2028
- Enrollment
- 259 participants
- Sites
- 1
- Primary outcomes
- Correlation Between Local Control and Changes in Mass Transport by Computed Tomography (CT)
- Sponsor
- Other
- Results posted
- No
- Last update
- 21 July 2026
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Brief summary public domain (ClinicalTrials.gov)
This trial studies how well computed tomography works in diagnosing patients with pancreatic or hepatobiliary cancer. Computed tomography may help researchers predict how patients with pancreatic or hepatobiliary cancer may respond to chemotherapy.
Detailed description public domain (ClinicalTrials.gov)
PRIMARY OBJECTIVES: I. To prospectively validate our pilot data that indicate that pre-therapy computed tomography-based (CT) mass transport properties correlate with overall survival. II. To prospectively validate our pilot data that indicate that local control of pancreatic and hepatobiliary tumors correlate with changes in computed tomography-based mass transport properties of the tumors after cytotoxic therapies. OUTLINE: Patients undergo CT scan at baseline and after 4 to 6 cycles of fluorouracil/irinotecan/leucovorin calcium/oxaliplatin, or after 4 infusions of gemcitabine/nab-paclitaxel (or other gemcitabine-based regimens), or 6 to 12 weeks after radiotherapy for hepatobiliary cancers. Patients may undergo optional magnetic resonance imaging (MRI) scans prior to therapy, after two weeks of therapy, and at the time of the first restaging CT scan.