Clinical trialPhase 2Unknown
The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma
- Outcome
- Outcome unknown
- Phase
- Phase 2
- Status
- Unknown
- Study type
- Interventional
- Start
- January 2019
- Expected end
- January 2021
- Enrollment
- 20 participants
- Sites
- 1
- Primary outcomes
- The effect of neoadjuvant metformin treatment on tumour cell proliferation in PDAC tumours
- Sponsor
- Other
- Results posted
- No
- Last update
- 18 January 2018
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Papers 12
- BackgroundPrognostic relevance of apparent diffusion coefficient obtained by diffusion-weighted MRI in pancreatic cancer. DOI 10.1002/jmri.24939↗
- BackgroundDetection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer. DOI 10.1002/cncr.29364↗
- BackgroundA pilot study of diffusion-weighted MRI in patients undergoing neoadjuvant chemoradiation for pancreatic cancer. DOI 10.1016/j.tranon.2014.07.005↗
- BackgroundDetection of circulating tumor DNA in early- and late-stage human malignancies. DOI 10.1126/scitranslmed.3007094↗
- BackgroundAntidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR S… DOI 10.1593/tlo.13556↗
- BackgroundMetformin targets the metabolic achilles heel of human pancreatic cancer stem cells. DOI 10.1371/journal.pone.0076518↗
- BackgroundNew insights into pancreatic cancer-induced paraneoplastic diabetes. DOI 10.1038/nrgastro.2013.49↗
- BackgroundMetformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on gl… DOI 10.1016/j.bbrc.2012.11.010↗
- BackgroundThe clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: An evide… DOI 10.3978/j.issn.2078-6891.2011.021↗
- BackgroundMetformin use is associated with better survival of diabetic patients with pancreatic cancer. DOI 10.1158/1078-0432.ccr-11-2994↗
- BackgroundRandomized phase II study of gemcitabine plus radiotherapy versus gemcitabine, 5-fluorouracil, and cisplatin followed b… DOI 10.1002/jso.21527↗
- BackgroundNew-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer. DOI 10.1016/s1470-2045(08)70337-1↗