Clinical trialPhase 1 / Phase 2Terminated
A Study of SLC-0111 and Gemcitabine for Metastatic Pancreatic Ductal Cancer in Subjects Positive for CAIX
An Open-label, Multi-center, Phase 1b Study to Investigate the Safety and Tolerability of SLC-0111 (WBI-5111) in Combination With Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma Subjects Positive for Carbonic Anhydrase IX
- Outcome
- Stopped earlyChanging treatment landscape: The availability of nab-paclitaxel with gemcitabine in the second-line setting has changed the feasibility of further recruitment and potential long-term development opportunities of SLC-0111 with gemcitabine alone. (Enrollment)
- Phase
- Phase 1 / Phase 2
- Status
- Terminated
- Study type
- Interventional
- Start
- 10 January 2019
- Expected end
- 16 May 2024
- Enrollment
- 6 participants
- Sites
- 2
- Primary outcomes
- Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
- Sponsor
- Other
- Results posted
- No
- Last update
- 24 May 2024
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Papers 14
- BackgroundTherapeutic Advances in Localized Pancreatic Cancer. DOI 10.1001/jamasurg.2016.1113↗
- BackgroundRecent Trends in Survival of Patients With Pancreatic Cancer in Germany and the United States. DOI 10.1097/mpa.0000000000000588↗
- BackgroundMetastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline. DOI 10.1200/jco.2016.67.1412↗
- BackgroundLocalized Pancreatic Cancer: Multidisciplinary Management. DOI 10.1200/edbk_160827↗
- BackgroundThe role of hypoxia in pancreatic cancer: a potential therapeutic target? DOI 10.1586/17474124.2016.1117386↗
- BackgroundGemcitabine plus nab-paclitaxel for advanced pancreatic cancer after first-line FOLFIRINOX: single institution retrospe… DOI 10.1186/s40164-015-0025-y↗
- BackgroundNab-paclitaxel plus gemcitabine for metastatic pancreatic adenocarcinoma after Folfirinox failure: an AGEO prospective … DOI 10.1038/bjc.2015.328↗
- BackgroundIncreased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. DOI 10.1056/nejmoa1304369↗
- BackgroundAdjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO… DOI 10.1001/jama.2013.279201↗
- BackgroundStrengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma. DOI 10.1073/pnas.1219555110↗
- Background5-fluorouracil/leucovorin combined with irinotecan and oxaliplatin (FOLFIRINOX) as second-line chemotherapy in patients… DOI 10.1159/000329803↗
- BackgroundFOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. DOI 10.1056/nejmoa1011923↗
- BackgroundHypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of… DOI 10.1158/0008-5472.can-10-4049↗
- BackgroundNew response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). DOI 10.1016/j.ejca.2008.10.026↗