Clinical trialPhase 2 / Phase 3Suspended
Acelarin First Line Randomised Pancreatic Study
A Phase III, Open Label, Multicentre Randomised Clinical Study Comparing Acelarin (NUC-1031) With Gemcitabine in Patients With Metastatic Pancreatic Carcinoma
- Outcome
- Stopped earlySuspended to recruitment following TSC review on efficacy and toxicities (Toxicity)
- Phase
- Phase 2 / Phase 3
- Status
- Suspended
- Study type
- Interventional
- Start
- December 2015
- Expected end
- December 2022
- Enrollment
- 328 participants
- Sites
- 1
- Primary outcomes
- Number of participants that have survived throughout treatment and also into follow-up, as measured by the primary cause of death and date of death CRFs.
- Sponsor
- Other
- Results posted
- No
- Last update
- 29 October 2019
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Papers 5
- BackgroundGemcitabine: metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer. DOI 10.1016/j.ejphar.2014.07.041↗
- BackgroundHistorical controls for metastatic pancreatic cancer: benchmarks for planning and analyzing single-arm phase II trials. DOI 10.1158/1078-0432.ccr-13-2024↗
- BackgroundFOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. DOI 10.1056/nejmoa1011923↗
- BackgroundErlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III tri… DOI 10.1200/jco.2006.07.9525↗
- BackgroundImmunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mech… DOI 10.1158/1078-0432.ccr-05-2655↗