Clinical trialNACompleted

Internet Based Cognitive Behavioral Therapy in Pediatric Chronic Pancreatitis

A Randomized Trial of a Web-based Non-pharmacological Pain Intervention for Pediatric Chronic Pancreatitis

NCT03707431 ↗ ClinicalTrials.gov, retrieved 6 November 2026

Outcome: Outcome unknown
Phase: NA
Status: Completed
Study type: Interventional
Start: 25 April 2019
Expected end: 31 July 2024
Enrollment: 90 participants
Sites: 1
Primary outcomes: Change in Adolescent Abdominal Pain Severity
Sponsor: Other
Results posted: 2026-04-09
Last update: 9 April 2026

These are registry fields. A trial card, with population, design, endpoints and result direction each tied to a quote, is not in the data yet.

Ask this document

Answers come only from this document’s own text, as highlighted quotes. If it doesn’t say, you are told so instead of given a guess.

Try

Source text

Brief summary public domain (ClinicalTrials.gov)

Abdominal pain is common in children with chronic and acute recurring pancreatitis (CP, ARP), and as they continue into adulthood, the disease progresses with increased pain and greater exposure to opioids. Despite the relevancy of early pain self-management for childhood pancreatitis, there have been no studies of non-pharmacological pain intervention in this population. The proposed project will evaluate a web-based cognitive behavioral pain management program delivered to a cohort of well-phenotyped children with CP/ARP and some community participants to reduce pain, pain-related disability and enhance HRQOL; it will also identify genetic risk factors and clinical and behavioral phenotypic factors associated with treatment response to enable precision medicine approaches.

Detailed description public domain (ClinicalTrials.gov)

Abdominal pain is present in 81% of children and adolescents with CP and ARP. Effective treatments that target pain in these children will lessen the risk of opioid exposure and continued pain and disability into adulthood. We plan to recruit a large multicenter sample of 260 children and adolescents (ages 10-19 years) with CP/ARP and their parents from INSPPIRE 2 (INSPPIRE:INternational Study Group of Pediatric Pancreatitis: In search for a cuRE) centers and pancreatitis community groups (e.g. NPF) to evaluate the efficacy of WebMAP, a web-based cognitive behavioral pain management program (CBT). The study design is a two (group) x three (time point) randomized, controlled, double-blinded trial. Participants will be randomly assigned to receive online access to either pain education (WebED) or CBT (WebMAP) over an 8-10 week treatment period. The primary study outcome is abdominal pain symptoms measured at pre-treatment, immediately post-treatment, and at 6-month follow-up. Secondary outcomes include pain-related disability, health-related quality of life, depression and anxiety symptoms, and medication use. This project represents a significant advance in pain management for children with CP/ARP by evaluating the first ever nonpharmacologic pain intervention in these patients, which may guide future developments in the management of chronic pain associated with CP/ARP.

Posted results (ClinicalTrials.gov registry) · primary outcome public domain (ClinicalTrials.gov)

Change in Adolescent Abdominal Pain Severity [Baseline, 12 weeks, 6 months]. Mean, scores on a scale (Standard Deviation). T1 (Baseline): Pain Education (WebED) (n=44): 2.11 (1.06); Web-based CBT (WebMAP) (n=46): 1.74 (1.61). T2 (Post-treatment, 12 weeks): Pain Education (WebED) (n=44): 1.99 (1.22); Web-based CBT (WebMAP) (n=46): 1.61 (1.19). T3 (6-month follow-up): Pain Education (WebED) (n=44): 1.62 (1.27); Web-based CBT (WebMAP) (n=46): 1.48 (1.19).