Pancreatic Cancer Research

Clinical trialNATerminated

EUS-guided Laser Ablation in Pancreatic Adenocarcinoma

EUS-guided Laser Complete Ablation of Advanced Pancreatic Ductal Adenocarcinoma: a Feasibility Study

NCT03784417↗ ClinicalTrials.gov, retrieved 6 November 2026

Outcome
Stopped earlydevice unavalaible (Other)
Phase
NA
Status
Terminated
Study type
Interventional
Start
15 October 2019
Expected end
15 December 2021
Enrollment
5 participants
Sites
2
Primary outcomes
Tumor necrosis induction by EUS-guided laser ablation (LA) - Number of patients with necrosis of the tumor
Sponsor
Other
Results posted
No
Last update
28 February 2022

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Brief summary public domain (ClinicalTrials.gov)

This study evaluates the possibility of performing local therapy for PDAC using laser ablation of the tumor under ultrasonography (EUS) guidance. Safety of the procedure as well as post procedural quality of life will be also evaluated.

Detailed description public domain (ClinicalTrials.gov)

Pancreatic adenocarcinoma (PDAC) is projected to be the second cause of cancer death in Western societies within a decade. Management include chemotherapy and/or radiation therapy, while resectable disease is possible only in 15% of cases. Despite these therapeutic approaches, the survival rate of unresectable pancreatic cancer remains disappointing. Recently, there is a growing interest in the development of alternative therapeutic approaches, which can work in parallel with standard chemoradiation therapy. These methods include intra-lesion injection/instillation of antitumoral agents performed through a laparoscopic approach, or percutaneously or under endoscopic ultrasound (EUS) guidance and tumor volume reduction procedures using ablative techniques. In this context laser ablation has been reported to be effective in inducing coagulative necrosis of the tumour in absence of major adverse events. However, the available studies on the matter are limited by small sample size, lack of extended follow up and informations about the possibility to ablate the entire tumour mass.

Papers 4