Clinical trialPhase 1Terminated
Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer
THREAD: A Phase I Trial of Trametinib and Hydroxychloroquine in Patients With Advanced Pancreatic Cancer
- Outcome
- Stopped earlyLack of Funding (Business decision)
- Phase
- Phase 1
- Status
- Terminated
- Study type
- Interventional
- Start
- 30 January 2019
- Expected end
- 3 August 2025
- Enrollment
- 25 participants
- Sites
- 2
- Primary outcomes
- Rate of dose-limiting toxicities during the DLT assessment window.
- Sponsor
- Other
- Results posted
- No
- Last update
- 14 May 2026
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Papers 10
- BackgroundLocally Advanced Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Summ… DOI 10.1200/jop.2016.017376↗
- BackgroundMetastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline. DOI 10.1200/jco.2016.67.1412↗
- BackgroundPancreatic cancer. DOI 10.1038/nrdp.2016.22↗
- BackgroundA phase I/Ib study of trametinib (GSK1120212) alone and in combination with gemcitabine in Japanese patients with advan… DOI 10.1007/s10637-015-0270-2↗
- BackgroundAddressing the challenges of pancreatic cancer: future directions for improving outcomes. DOI 10.1016/j.pan.2014.10.001↗
- BackgroundA randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitab… DOI 10.1016/j.ejca.2014.04.024↗
- BackgroundComparative benefits of Nab-paclitaxel over gemcitabine or polysorbate-based docetaxel in experimental pancreatic cance… DOI 10.1093/carcin/bgt227↗
- BackgroundAnalysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in dr… DOI 10.1158/1541-7786.mcr-12-0188↗
- BackgroundA central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. DOI 10.1158/2159-8290.cd-11-0347↗
- BackgroundGemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer. DOI 10.1016/j.ejca.2011.10.017↗