Clinical trialPhase 2Active not recruiting
1911GCCC: Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma
1911GCCC: Open Label, Phase 2 Trial of Galeterone Combined With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma Refractory to Standard Chemotherapy
- Outcome
- Ongoing
- Phase
- Phase 2
- Status
- Active not recruiting
- Study type
- Interventional
- Start
- 12 December 2019
- Expected end
- 31 December 2026
- Enrollment
- 15 participants
- Sites
- 1
- Primary outcomes
- response rate
- Sponsor
- Other
- Results posted
- No
- Last update
- 1 July 2026
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Papers 7
- BackgroundThe nab-paclitaxel/gemcitabine regimen for patients with refractory advanced pancreatic adenocarcinoma. DOI 10.21037/jgo.2017.10.12↗
- BackgroundGaleterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration,… DOI 10.18632/oncotarget.14154↗
- BackgroundIncreased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. DOI 10.1056/nejmoa1304369↗
- BackgroundA phase II trial of nab-Paclitaxel as second-line therapy in patients with advanced pancreatic cancer. DOI 10.1097/coc.0b013e3182436e8c↗
- BackgroundGemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway. DOI 10.1038/onc.2012.306↗
- BackgroundFOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. DOI 10.1056/nejmoa1011923↗
- BackgroundNew response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). DOI 10.1016/j.ejca.2008.10.026↗