Clinical trialPhase 1Completed
Exploratory Platform Trial to Evaluate Immunotherapy Combinations With Chemotherapy for the Treatment of Patients With Previously Untreated Metastatic Pancreatic Adenocarcinoma
A Multicenter, Open-label, ExploRatory Platform Trial to EValuate ImmunOtherapy Combinations With Chemotherapy for the Treatment of Patients With PreviousLy UnTreated MetastatIc Pancreatic AdenOcarciNoma (REVOLUTION)
- Outcome
- Finished, no results posted
- Phase
- Phase 1
- Status
- Completed
- Study type
- Interventional
- Start
- 9 August 2021
- Expected end
- 31 July 2025
- Enrollment
- 45 participants
- Sites
- 6
- Primary outcomes
- Incidence and severity of adverse events
- Sponsor
- Industry
- Results posted
- No
- Last update
- 30 October 2025
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Papers 20
- BackgroundCD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment… DOI 10.1016/s1470-2045(20)30532-5↗
- BackgroundAutophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. DOI 10.1038/s41586-020-2229-5↗
- BackgroundThe Tumor Microbiome in Pancreatic Cancer: Bacteria and Beyond. DOI 10.1016/j.ccell.2019.11.004↗
- BackgroundTumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. DOI 10.1016/j.cell.2019.07.008↗
- BackgroundCross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fib… DOI 10.1158/2159-8290.cd-19-0094↗
- BackgroundMaintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. DOI 10.1056/nejmoa1903387↗
- BackgroundMolecular subtypes of pancreatic cancer. DOI 10.1038/s41575-019-0109-y↗
- BackgroundMetabolic Dependencies in Pancreatic Cancer. DOI 10.3389/fonc.2018.00617↗
- BackgroundImmunotherapy and Prevention of Pancreatic Cancer. DOI 10.1016/j.trecan.2018.04.001↗
- BackgroundImmunotherapy in pancreatic adenocarcinoma-overcoming barriers to response. DOI 10.21037/jgo.2018.01.13↗
- BackgroundIdentification of unique neoantigen qualities in long-term survivors of pancreatic cancer. DOI 10.1038/nature24462↗
- BackgroundPancreatic Ductal Adenocarcinoma: Current and Evolving Therapies. DOI 10.3390/ijms18071338↗
- BackgroundPrevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer. DOI 10.1016/j.canlet.2016.02.057↗
- BackgroundIncreased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. DOI 10.1056/nejmoa1304369↗
- BackgroundAdjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO… DOI 10.1001/jama.2013.279201↗
- BackgroundSafety and activity of anti-PD-L1 antibody in patients with advanced cancer. DOI 10.1056/nejmoa1200694↗
- BackgroundFOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. DOI 10.1056/nejmoa1011923↗
- BackgroundPhase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. DOI 10.1097/cji.0b013e3181eec14c↗
- BackgroundNew response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). DOI 10.1016/j.ejca.2008.10.026↗
- BackgroundAdjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic ca… DOI 10.1001/jama.297.3.267↗