Clinical trialPhase 2Recruiting
Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer
Phase II Study of Neoadjuvant Folfirinox Chemotherapy Followed by Pembrolizumab Followed by Surgery for Patients With Localized, Resectable Adenocarcinoma of the Pancreas
- Outcome
- Ongoing
- Phase
- Phase 2
- Status
- Recruiting
- Study type
- Interventional
- Start
- 31 August 2022
- Expected end
- 21 May 2027
- Enrollment
- 30 participants
- Sites
- 3
- Primary outcomes
- Determine if the neoadjuvant FOLFIRINOX chemotherapy followed by pembrolizumab followed by surgery will improve the overall response rate (ORR) for patients with localized, resectable adenocarcinoma of the pancreas.
- Sponsor
- Other
- Results posted
- No
- Last update
- 4 August 2026
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Papers 9
- BackgroundSurvival Outcomes Associated With Clinical and Pathological Response Following Neoadjuvant FOLFIRINOX or Gemcitabine/Na… DOI 10.1097/sla.0000000000003468↗
- BackgroundFOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. DOI 10.1056/nejmoa1809775↗
- BackgroundLocally Advanced Pancreatic Cancer: Neoadjuvant Therapy With Folfirinox Results in Resectability in 60% of the Patients. DOI 10.1097/sla.0000000000001850↗
- BackgroundProjecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the Un… DOI 10.1158/0008-5472.can-14-0155↗
- BackgroundTherapy of locally advanced pancreatic adenocarcinoma: unresectable and borderline patients. DOI 10.1586/era.11.125↗
- BackgroundA decision model of therapy for potentially resectable pancreatic cancer. DOI 10.1016/j.jss.2011.08.022↗
- BackgroundFOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. DOI 10.1056/nejmoa1011923↗
- BackgroundBorderline resectable pancreatic cancer: what have we learned and where do we go from here? DOI 10.1245/s10434-010-1460-y↗
- BackgroundPreoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head. DOI 10.1200/jco.2007.15.8634↗