Michigan Genetic Hereditary Testing (MiGHT)

Brief summary public domain (ClinicalTrials.gov)

The primary purpose of this study is to compare three interventions, two experimental and one standard of care (usual care), to see if the experimental interventions will increase the likelihood of a participant obtaining guideline-concordant genetic testing. Eligible participants will be randomized (assigned) to one of the following interventions: 1) Virtual genetics navigator, a mobile-optimized website, designed by the investigators, that delivers tailored messages and content; 2) two motivational interviewing (MI) telephone calls delivered by trained genetics health coaches; or 3) usual care.

Detailed description public domain (ClinicalTrials.gov)

This trial will be conducted in partnership with the Michigan Department of Health and Human Services (MDHHS) and a network of oncology practices in Michigan, the Michigan Oncology Quality Consortium (MOQC). As of April 2023 we were approved by our IRB to expand our inclusion criteria and recruitment cohort. This expansion will enhance our reach to individuals who are not in the acute stages of clinical care as well as individuals who are not in oncology care currently yet still qualify for genetic testing based on their family history of cancer alone or in combination with any personal cancer history. These expansions will also support the unburdening of oncology practices - who continue to face downstream, resource-limiting affects from the COVID-19 pandemic - across the state. The goal and aims of the study remain the same.

Posted results (ClinicalTrials.gov registry) · primary outcome public domain (ClinicalTrials.gov)

Percentage of Participants Who Complete Clinical Genetic Testing at Six Months After Randomization [6 months after enrollment/randomization]. Count Of Participants, Participants. Arm 1 - Usual Care (UC) (n=230): 5; Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=205): 15; Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=201): 11.

Posted results (ClinicalTrials.gov registry) · secondary outcome public domain (ClinicalTrials.gov)

Barriers to Genetic Testing, for Participants Who Completed Genetic Testing [6 months and 12 months after enrollment/randomization]. Mean, score on a scale (Standard Deviation). Q1: Convincing my doctor I needed testing- 6 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.20 (0.45); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.57 (1.16); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.0 (0). Q1: Convincing my doctor I needed testing- 12 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.0 (0); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.38 (1.06); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.13 (0.56). Q2: Finding out how to get testing- 6 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.0 (0); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.57 (1.02); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.09 (0.30). Q2: Finding out how to get testing- 12 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.36 (0.63); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.33 (0.76); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.13 (0.56). Q3: Finding time to get tested- 6 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.0 (0); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.14 (0.53); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.0 (0). Q3: Finding time to get tested- 12 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.40 (0.74); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.25 (0.61); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.06 (0.25). Q4: Figuring out how to pay for testing- 6 Month Survey: Arm 1 - Usual Care (UC) (n=27): 2.80 (2.05); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.64 (1.08); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.55 (0.82). Q4: Figuring out how to pay for testing- 12 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.40 (1.12); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.42 (0.72); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.39 (0.95). Q5: Getting ready emotionally to receive results- 6 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.60 (0.55); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.29 (0.73); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.55 (0.82). Q5: Getting ready emotionally to receive results- 12 Month Survey: Arm 1 - Usual Care (UC) (n=27): 2.07 (1.10); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=42): 1.83 (1.20); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=32): 1.58 (1.06). Q6: Understanding why testing was important for me- 6 Month Survey: Arm 1 - Usual Care (UC) (n=27): 1.80 (0.84); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n

Posted results (ClinicalTrials.gov registry) · secondary outcome public domain (ClinicalTrials.gov)

Barriers to Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing [6 months and 12 months after enrollment/randomization]. Mean, score on a scale (Standard Deviation). Q1: Getting genetic testing would cost me too much money- 6 Month Survey: Arm 1 - Usual Care (UC) (n=218): 2.88 (1.04); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 2.86 (1.16); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 2.85 (1.01). Q1: Getting genetic testing would cost me too much money- 12 Month Survey: Arm 1 - Usual Care (UC) (n=218): 2.82 (1.05); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 2.90 (1.24); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 2.93 (1.13). Q2: I worry that my health insurance would not cover the cost of genetic testing- 6 Month Survey: Arm 1 - Usual Care (UC) (n=218): 3.28 (1.19); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 3.28 (1.30); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.31 (1.15). Q2: I worry that my health insurance would not cover the cost of genetic testing- 12 Month Survey: Arm 1 - Usual Care (UC) (n=218): 3.30 (1.23); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 3.35 (1.21); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.25 (1.25). Q3: I would worry about how genetic testing would affect my health insurance rates- 6 Month Survey: Arm 1 - Usual Care (UC) (n=218): 2.82 (1.29); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 2.77 (1.32); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.01 (1.25). Q3: I would worry about how genetic testing would affect my health insurance rates- 12 Month Survey: Arm 1 - Usual Care (UC) (n=218): 2.84 (1.28); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 2.93 (1.25); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 2.92 (1.26). Q4: If I were found to carry an altered gene, I worry it would affect my life insurance- 6 Month: Arm 1 - Usual Care (UC) (n=218): 2.53 (1.24); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 2.64 (1.31); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 2.74 (1.18). Q4: If I were found to carry an altered gene, I worry it would affect my life insurance- 12 Month: Arm 1 - Usual Care (UC) (n=218): 2.58 (1.24); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 2.52 (1.21); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 2.70 (1.24). Q5: If found to carry an altered gene, I worry it would affect my insurance eligibility- 6 Month: Arm 1 - Usual Care (UC) (n=218): 2.87 (1.26); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=185): 2.72 (1.29); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 2.98 (1.28). Q5: If found to carry an altered gene, I worry it wo

Posted results (ClinicalTrials.gov registry) · secondary outcome public domain (ClinicalTrials.gov)

Motivators of Genetic Testing, for Participants Who Completed Genetic Testing [6 months and 12 months after enrollment/randomization]. Mean, score on a scale (Standard Deviation). Q1: Knowing my genetic status could help me plan my treatment- 6 Month Survey: Arm 1 - Usual Care (UC) (n=15): 2.50 (2.12); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 3.92 (1.24); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 3.89 (1.69). Q1: Knowing my genetic status could help me plan my treatment- 12 Month Survey: Arm 1 - Usual Care (UC) (n=15): 3.27 (1.68); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 3.62 (1.53); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 3.58 (1.59). Q2: Knowing my genetic status would impact my cancer screening- 6 months: Arm 1 - Usual Care (UC) (n=15): 3.40 (1.52); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 2.86 (1.51); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 3.45 (1.57). Q2: Knowing my genetic status would impact my cancer screening- 12 months: Arm 1 - Usual Care (UC) (n=15): 4.00 (1.36); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 3.71 (1.57); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 3.55 (1.46). Q3: I would be relieved to know my risk for hereditary cancer- 6 months: Arm 1 - Usual Care (UC) (n=15): 3.80 (0.84); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 4.14 (1.03); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 4.18 (0.98). Q3: I would be relieved to know my risk for hereditary cancer- 12 months: Arm 1 - Usual Care (UC) (n=15): 4.00 (1.51); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 4.38 (1.10); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 4.16 (1.29). Q4: I wanted to make sure my family had information that could affect their health- 6 months: Arm 1 - Usual Care (UC) (n=15): 4.40 (0.89); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 4.36 (0.84); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 4.45 (0.93). Q4: I wanted to make sure my family had information that could affect their health- 12 months: Arm 1 - Usual Care (UC) (n=15): 4.00 (1.20); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 4.58 (0.72); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 4.39 (1.12). Q5: A healthcare provider recommended it- 6 months: Arm 1 - Usual Care (UC) (n=15): 3.80 (1.30); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 2.36 (1.34); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=31): 3.09 (1.64). Q5: A healthcare provider recommended it- 12 months: Arm 1 - Usual Care (UC) (n=15): 3.60 (1.45); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=24): 2.83 (1.43); Arm 3 - Motivational Interviewing (MI) (Genetic Health Co

Posted results (ClinicalTrials.gov registry) · secondary outcome public domain (ClinicalTrials.gov)

Motivators of Genetic Testing, for Participants Who Did Not Yet Complete Genetic Testing [6 months and 12 months after enrollment/randomization]. Mean, score on a scale (Standard Deviation). Q1: Knowing my genetic status could help me plan my treatment- 6 Month Survey: Arm 1 - Usual Care (UC) (n=220): 3.80 (0.86); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.63 (0.88); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 3.64 (0.91). Q1: Knowing my genetic status could help me plan my treatment- 12 Month Survey: Arm 1 - Usual Care (UC) (n=220): 3.69 (0.91); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.61 (0.93); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 3.52 (0.90). Q2: Knowing my genetic status would impact my cancer screening- 6 months: Arm 1 - Usual Care (UC) (n=220): 3.65 (1.04); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.67 (0.86); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 3.51 (0.96). Q2: Knowing my genetic status would impact my cancer screening- 12 months: Arm 1 - Usual Care (UC) (n=220): 3.62 (0.96); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.59 (0.98); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 3.44 (0.96). Q3: I would be relieved to know my risk for hereditary cancer- 6 months: Arm 1 - Usual Care (UC) (n=220): 3.71 (0.90); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.60 (0.86); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 3.66 (0.91). Q3: I would be relieved to know my risk for hereditary cancer- 12 months: Arm 1 - Usual Care (UC) (n=220): 3.63 (0.93); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.62 (0.92); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 3.63 (0.98). Q4: I want to make sure my family has information that could affect their health- 6 months: Arm 1 - Usual Care (UC) (n=220): 4.17 (0.81); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 4.16 (0.70); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 4.15 (0.76). Q4: I want to make sure my family has information that could affect their health- 12 months: Arm 1 - Usual Care (UC) (n=220): 4.04 (0.95); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.99 (0.82); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 3.96 (0.81). Q5: A healthcare provider recommended it- 6 Months: Arm 1 - Usual Care (UC) (n=220): 3.54 (0.97); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.29 (1.07); Arm 3 - Motivational Interviewing (MI) (Genetic Health Coaching) (n=182): 3.47 (1.05). Q5: A healthcare provider recommended it- 12 Months: Arm 1 - Usual Care (UC) (n=220): 3.37 (1.05); Arm 2 - Virtual Genetics Navigator (Digital Intervention) (n=189): 3.41 (1.13); Arm 3 - Motivational