Clinical trialPhase 3Recruiting
Adjuvant Chemoradiotherapy Versus Chemotherapy for Pancreatic Cancer (ADJUPANC)
Adjuvant Chemoradiotherapy Versus Chemotherapy for Post-operative Pancreatic Cancer
- Outcome
- Ongoing
- Phase
- Phase 3
- Status
- Recruiting
- Study type
- Interventional
- Start
- 6 August 2024
- Expected end
- 30 June 2029
- Enrollment
- 770 participants
- Sites
- 1
- Primary outcomes
- Disease progression free survival will be determined.
- Sponsor
- Other
- Results posted
- No
- Last update
- 4 February 2025
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Brief summary public domain (ClinicalTrials.gov)
In this trial, we aim to compare the outcomes of adjuvant chemoradiotherapy with chemotherapy for patients with resected pancreatic cancer who are at high risk of disease progressions.
Detailed description public domain (ClinicalTrials.gov)
Pancreatic cancer is a lethal malignancy with the lowest 5-year overall survival rate of 9% and an increasing incidence. In China, the mortality of pancreatic cancer ranked the sixth among all cancers. Although surgical resection is the only radical treatment, only less than 20% patients could receive upfront surgery at the initial diagnosis. Even though patients have surgery, the incidence of disease progressions, including local progression and metastasis, is about 80-90%. In NCCN guidelines and Chinese guidelines, adjuvant chemotherapy is recommended for post-operative pancreatic cancer, while adjuvant chemoradiotherapy could also be used. However, it has not been clarified that which patients may benefit from adjuvant chemoradiotherapy, and no high-level evidence has shown the advantages of adjuvant chemoradiotherapy over chemotherapy. In meta-analyses, it was demonstrated that patients with lymph nodes metastases, R1 or R2 resection or lymphovascular invasion could achieve longer survival after adjuvant chemoradiotherapy compared with chemotherapy. Therefore, we aim to compare the outcomes of adjuvant chemoradiotherapy with those of chemotherapy in patients with lymph nodes metastases, R1 or R2 resection or lymphovascular invasion after surgical resection of pancreatic cancer.