Clinical trialNARecruiting
Using Tumour DNA and Proteins to Better Understand How Pancreatic Cancer Responds to Treatment
Accelerating the Actionability of Treatment in Resected and Locally Advanced Pancreatic Cancer
- Outcome
- Ongoing
- Phase
- NA
- Status
- Recruiting
- Study type
- Interventional
- Start
- 28 November 2025
- Expected end
- December 2031
- Enrollment
- 200 participants
- Sites
- 1
- Primary outcomes
- Frequency of comprehensive genomic results returned within 8 weeks of sample collection.
- Sponsor
- Other
- Results posted
- No
- Last update
- 16 September 2026
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Papers 21
- BackgroundSotorasib in KRAS p.G12C-Mutated Advanced Pancreatic Cancer. DOI 10.1056/nejmoa2208470↗
- BackgroundGATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer. DOI 10.1158/1078-0432.ccr-19-3724↗
- BackgroundRandomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancrea… DOI 10.1200/jco.19.02931↗
- BackgroundTranscription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution. DOI 10.1038/s41588-019-0566-9↗
- BackgroundAltered Gene Expression along the Glycolysis-Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer. DOI 10.1158/1078-0432.ccr-19-1543↗
- BackgroundOncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer. DOI 10.1158/1078-0432.ccr-19-1280↗
- BackgroundMaintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. DOI 10.1056/nejmoa1903387↗
- BackgroundNRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocar… DOI 10.1158/1078-0432.ccr-19-0191↗
- BackgroundMolecular subtypes of pancreatic cancer. DOI 10.1038/s41575-019-0109-y↗
- BackgroundFOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. DOI 10.1056/nejmoa1809775↗
- BackgroundTemporal Dynamics of Genomic Alterations in a BRCA1 Germline-Mutated Pancreatic Cancer With Low Genomic Instability Bur… DOI 10.1200/po.18.00057↗
- BackgroundGenomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial. DOI 10.1158/1078-0432.ccr-17-2994↗
- BackgroundComparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic c… DOI 10.1016/s0140-6736(16)32409-6↗
- BackgroundNew targeted therapies in pancreatic cancer. DOI 10.3748/wjg.v21.i20.6127↗
- BackgroundWhole genomes redefine the mutational landscape of pancreatic cancer. DOI 10.1038/nature14169↗
- Backgroundnab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial. DOI 10.1093/jnci/dju413↗
- BackgroundAdjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO… DOI 10.1001/jama.2013.279201↗
- BackgroundPancreatic ductal adenocarcinoma: long-term survival does not equal cure. DOI 10.1016/j.surg.2012.05.020↗
- BackgroundFOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. DOI 10.1056/nejmoa1011923↗
- BackgroundErlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III tri… DOI 10.1200/jco.2006.07.9525↗
- BackgroundAdjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic ca… DOI 10.1001/jama.297.3.267↗