Clinical trialPhase 1Suspended
Stereotactic Centralized Ablative Radiotherapy for Locally Advanced Pancreatic Cancer: A Single-Arm Phase I Safety and Feasibility Study
- Outcome
- Stopped earlyThe study was terminated early due to slow patient accrual. Enrollment was substantially lower than anticipated, making it unlikely to achieve the planned sample size within a reasonable timeframe. (Enrollment)
- Phase
- Phase 1
- Status
- Suspended
- Study type
- Interventional
- Start
- 10 September 2025
- Expected end
- 1 September 2028
- Enrollment
- 24 participants
- Sites
- 1
- Primary outcomes
- Maximum Tolerated Dose (MTD); Dose-Limiting Toxicities (DLTs)
- Sponsor
- Other
- Results posted
- No
- Last update
- 1 May 2026
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Papers 12
- BackgroundTumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer: Systematic Review and Still-Op… DOI 10.3390/cancers13133119↗
- BackgroundPancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. DOI 10.1038/s41575-021-00457-x↗
- BackgroundRole of FOLFIRINOX and chemoradiotherapy in locally advanced and borderline resectable pancreatic adenocarcinoma: updat… DOI 10.1038/s41416-021-01341-w↗
- BackgroundNovel strategies using modern radiotherapy to improve pancreatic cancer outcomes: toward a new standard? DOI 10.1177/1758835920936093↗
- BackgroundThe Role of Radiation Therapy for Pancreatic Cancer in the Adjuvant and Neoadjuvant Settings. DOI 10.1016/j.soc.2017.01.012↗
- BackgroundEffect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled … DOI 10.1001/jama.2016.4324↗
- BackgroundSurgery for Localized Pancreatic Cancer: The Trend Is Not Improving. DOI 10.1097/mpa.0000000000000511↗
- BackgroundProjecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the Un… DOI 10.1158/0008-5472.can-14-0155↗
- BackgroundIncreased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. DOI 10.1056/nejmoa1304369↗
- BackgroundGemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern … DOI 10.1200/jco.2011.34.8904↗
- BackgroundFOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. DOI 10.1056/nejmoa1011923↗
- BackgroundPhase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) fol… DOI 10.1093/annonc/mdn281↗