Clinical trialPhase 2Not yet recruiting
Fecal Microbiota Transplantation Combined With NALIRIFOX Plus Serplulimab as First-line Treatment for Advanced or Metastatic Pancreatic Ductal Adenocarcinoma.
Fecal Microbiota Transplantation Combined With NALIRIFOX Plus Serplulimab as First-line Treatment for Advanced or Metastatic Pancreatic Ductal Adenocarcinoma: A Randomized, Open-Label, Single-Center, Parallel-Group, Prospective Phase II Clinical Study.
- Outcome
- Ongoing
- Phase
- Phase 2
- Status
- Not yet recruiting
- Study type
- Interventional
- Start
- November 2026
- Expected end
- May 2030
- Enrollment
- 40 participants
- Sites
- 1
- Primary outcomes
- Median Progression-Free Survival (mPFS)
- Sponsor
- Other
- Results posted
- No
- Last update
- 2 October 2026
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Papers 10
- BackgroundNALIRIFOX in the frontline for metastatic pancreatic cancer: evidence beyond NAPOLI 3. DOI 10.1038/s41571-024-00952-5↗
- BackgroundGlobal cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. DOI 10.3322/caac.21834↗
- BackgroundCancer statistics, 2024. DOI 10.3322/caac.21820↗
- BackgroundNALIRIFOX versus nab-paclitaxel and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarc… DOI 10.1016/s0140-6736(23)01366-1↗
- BackgroundThe CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial t… DOI 10.1038/s41467-022-32591-8↗
- BackgroundChallenges and Opportunities for Pancreatic Cancer Immunotherapy. DOI 10.1016/j.ccell.2020.08.004↗
- BackgroundPancreatic cancer. DOI 10.1016/s0140-6736(20)30974-0↗
- BackgroundThe tumour microenvironment in pancreatic cancer - clinical challenges and opportunities. DOI 10.1038/s41571-020-0363-5↗
- BackgroundTumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. DOI 10.1016/j.cell.2019.07.008↗
- BackgroundThe Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. DOI 10.1158/2159-8290.cd-17-1134↗