Journal articleNat Med2019
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
- Journal
- Nat Med
- Published
- 4 March 2019
- Citations
- 612
- Type
- Article
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Trials 1
Grants 19
- Validation of WEE1 kinase as a clinical target in KRAS-mutant pancreatic cancer F30CA243253↗
- K-Ras mutant-specific vulnerabilities for novel pancreatic cancer therapies F32CA200313↗
- Defining the contributions of WT RAS in RAS-mutant lung cancer F32CA232529↗
- Defining the roles of ERK MAPK in driving KRAS-mutant pancreatic cancer growth. F32CA239328↗
- Core C-Computational Core P01CA117969↗
- Project 3: Mechanisms and therapeutic targeting of NRAS in melanoma P01CA203657↗
- Targets, Modulators and Delivery Program P30CA036727↗
- Tissue Core P50CA127297↗
- Project 1: Overcoming Tumor-Induced Immune Suppression to Improve Responses to Immunotherapy P50CA196510↗
- Biological Activity of Ras Oncogenes R01CA042978↗
- Investigating the Role of Autophagy in Pancreatic Cancer Radiation Resistance R01CA157490↗
- Targeting Tumor-Stromal Metabolic Cross-Talk in Pancreatic Cancer R01CA163649↗
- Mechanisms of PAK1 activation, signaling and tumor resistance R01CA175747↗
- Investigating a novel glutamine metabolism pathway in pancreatic cancer R01CA188048↗
- Targeting the Metabolic Basis of Cachexia in Pancreatic Cancer R01CA210439↗
- Metabolic Regulation of Tumor Progression, Metastasis and Chemoresistance by SIRT5/ELK3 signaling in Pancreatic Cancer R01CA216853↗
- Targeting undruggable RAS for cancer treatment R35CA232113↗
- Identifying Metabolic Dependencies of Pancreatic Cancers R35CA232124↗
- Identification of synthetic lethal interactors in pancreatic cancer U01CA199235↗