Clinical trialPhase 2Completed
SBRT Plus Pembrolizumab and Trametinib for Pancreatic Cancer
Stereotactic Body Radiation Therapy Plus Pembrolizumab and Trametinib vs. Stereotactic Body Radiation Therapy Plus Gemcitabine for Locally Recurrent Pancreatic Cancer After Surgical Resection: an Open-label, Randomized, Controlled, Phase 2 Trial
- Outcome
- Outcome unknown
- Phase
- Phase 2
- Status
- Completed
- Study type
- Interventional
- Start
- October 2016
- Expected end
- December 2020
- Enrollment
- 170 participants
- Sites
- 1
- Primary outcomes
- The Median Survival Time Will be Determined.
- Sponsor
- Other
- Results posted
- 2021-02-16
- Last update
- 13 May 2022
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Papers 10
- Builds on itEffect of stereotactic body radiotherapy dose escalation plus pembrolizumab and trametinib versus stereotactic body rad… DOI 10.1016/j.eclinm.2022.101764↗
- Builds on itStereotactic body radiotherapy plus pembrolizumab and trametinib versus stereotactic body radiotherapy plus gemcitabine… DOI 10.1016/s1470-2045(22)00066-3↗
- Builds on itRETRACTION: Stereotactic body radiotherapy plus pembrolizumab and trametinib versus stereotactic body radiotherapy plus… DOI 10.1016/s1470-2045(21)00286-2↗
- BackgroundCombination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. DOI 10.1038/s41591-019-0368-8↗
- BackgroundGenomic analyses identify molecular subtypes of pancreatic cancer. DOI 10.1038/nature16965↗
- BackgroundThe MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Re… DOI 10.1158/1078-0432.ccr-15-0485↗
- BackgroundOncogenic KRAS signalling in pancreatic cancer. DOI 10.1038/bjc.2014.215↗
- BackgroundAdjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO… DOI 10.1001/jama.2013.279201↗
- BackgroundSafety and activity of anti-PD-L1 antibody in patients with advanced cancer. DOI 10.1056/nejmoa1200694↗
- BackgroundPhase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. DOI 10.1097/cji.0b013e3181eec14c↗